by University of Portsmouth, School of Pharmacy and Biomedical Sciences in Portsmouth .
Written in English
Thesis (Ph.D.) - University of Portsmouth, 2000.
|Statement||by Chuleratana Banchonglikitkul.|
Lectins in drug delivery to the eye and mouth. Author: Banchonglikitkul, Chuleratana. ISNI: Awarding Body: University of Portsmouth Current Institution: University of Portsmouth Date of Award: Availability of Full Text. Ocular drug delivery is limited both by patient acceptability and by the limited time that the dosage form is retained within the precorneal region. A previous in‐vitro study identified the lectins from Solanum tuberosum (potato) and Helix pomatia (edible snail) as avid and stable binders to ocular tissues. This study evaluated the in‐vivo retention and toxicity of these two lectins in both anaesthetized, and Cited by: 5. The potential for using lectins as a means of ‘anchoring’ a drug delivery system to the mucosal surfaces of the eye has been investigated in previous work, with the lectins from Solanum tuberosum and Helix pomatia showing particular promise. In this study the acute local dermal irritancy of these lectins, in terms of their potential to cause inflammation and tissue necrosis, was by: Selective targeting of drugs to the proposed site of action provides therapeutic advantages such as reduced toxicity and smaller dose levels. Despite a huge progress made in drug design and delivery systems, many challenges still have to be solved. Small therapeutic drugs always have the potential to pass into the kidneys and be excreted from the by:
Lectins in drug delivery to the oral cavity, in vitro toxicity studies Article in S.T.P. Pharma Sciences 13(1) January with 7 Reads How we measure 'reads'. Books Advanced Search New Releases Best Sellers & More Children's Books Textbooks Textbook Rentals Sell Us Your Books Best Books of the Month of results for Books: "lectins" Skip to main search results. covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions. examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles. describes vaginal, nasal, buccal, ocular, and transdermal drug delivery.5/5(1). lectin activity Lectin content may be reduced by 59% by sprouting (e.g. soybeans)51 and may be reduced by up to 95% by fermenting as is the case with tempeh, a fermented soybean food. 52 History suggests that traditionally prepared grains were first fermented or sprouted, in effect reducing theirFile Size: KB.
The book comes with a big, controversial claim: Gundry says a broad group of plant proteins called lectins — found in grains; beans and legumes; nuts; fruits; nightshade vegetables Author: Bahar Gholipour. The concept of lectin-mediated specific drug delivery was proposed by Woodley and Naisbett in (Bies et al., ). Delivery of targeted therapeutics via direct and reverse drug delivery systems (DDS) to specific sites provides numerous advantages over traditional non-targeted therapeutics (Minko, ; Plattner et al., ; Rek et al., ).Cited by: A lectin called phytohemagglutinin found in raw beans (red kidney beans in particular) binds to a carbohydrate present on human intestinal cells. This lectin is inactivated by cooking. If you use dry beans, take the necessary precaution of making sure they are thoroughly cooked – don’t eat undercooked beans. Lectins have also been used for several biotechnological applications, including drug delivery  and disease diagnosis , as well as facilitating glycomic studies. Furthermore, these lectins.